Teaching

Lecture Notes

Chemical Exchange (2025)

Slides from a lecture (10 Dec 2025) to the London NMR Theory Club on chemical exchange in NMR.

  1. Chemical Exchange

Introduction to Biomolecular NMR (2015)

Lecture notes / slides provided from a two-term graduate-level course in biomolecular NMR.

  1. Introduction
  2. 1D NMR
  3. Processing
  4. 2D NMR, part I
  5. Basic protein characterisation
  6. Diffusion
  7. Calibration
  8. 2D NMR, part II
  9. 2D NMR, part III
  10. 3D NMR
  11. Quantum mechanics, part I
  12. Quantum mechanics, part II
  13. Relaxation
  14. Longitudinal relaxation and the NOE
  15. Transverse relaxation
  16. Chemical exchange, part I
  17. Chemical exchange, part II
  18. TROSY
  19. Strong coupling
  20. Methyl relaxation

These works are licensed under a Creative Commons Attribution 4.0 International License.

Interactive workbooks

Pluto (Julia) workbooks for the exploration of chemical exchange in NMR

A pair of interactive workbooks, written in Julia using Pluto, are available for the exploration of chemical exchange in one-dimensional NMR. Exchange parameters can be varied using the sliders provided, and plots can be saved as pdfs for use in teaching material or other purposes. These notebooks can be downloaded from GitHub and run locally. Alternatively, they can be run through your browser directly through Binder using the links below. Please note that this may be slow to launch.

1D two-state chemical exchange simulation
1D titration simulation

Citation: Waudby CA, Alfonso I. J Magn Reson Open 16-17 100102 (2023). An introduction to one- and two-dimensional lineshape analysis of chemically exchanging systems.

Video Lectures

Two-dimensional lineshape analysis of biomolecular interactions

22 June 2021, Global NMR Discussion Meetings.